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BIO89-100, on the other hand, appears to deliver relative hepatic fat loss in between efruxifermin and pegbelfermin, with the highest dose reducing fat content by 60% in NAFLD patients, and all other doses reducing fat content by 3650% (299)

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Consequently, product labeling for agents such as semaglutide and tirzepatide advises discontinuation at least two months before planned conception to allow for pharmacokinetic clearance

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