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When to contact a healthcare provider : Patients should seek medical advice if they experience: Severe or persistent abdominal pain, especially if radiating to the back (potential pancreatitis) Right upper quadrant pain, fever, or yellowing of skin/eyes (potential gallbladder disease) Inability to pass gas or stool for more than 3 days Vomiting that prevents adequate hydration Signs of dehydration (dark urine, dizziness, decreased urination) Blood in stool or black, tarry stools Unintentional weight loss exceeding expected therapeutic effects New or worsening symptoms after several weeks of stable treatment Patients experiencing persistent gastrointestinal symptoms should discuss with their provider whether adjusting the tirzepatide dose escalation schedule or temporarily holding at a lower dose might improve tolerability while maintaining therapeutic benefits

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Signs of dehydration: Symptoms like dry mouth, extreme thirst, dizziness, and dark urine suggest dehydration, which can be dangerous if not treated

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A 2018 study by Jain et al