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Risk may increase when: Intake declines GI symptoms persist Dietary diversity narrows Evidence strength: Moderate plausibility

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This was supported in 5xFAD mice, in which exendin-4 treatment alleviated cognitive dysfunction, prevented amyloid- accumulation, and protected mitochondrial function [54]

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Patients treated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for treating type 2 diabetes (T2D) and for weight management have reported reduced desire to drink and smoke