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By targeting both the tumor and immune components of the TME, such as MDSCs, TAMs, and other suppressive cells, the efficacy of immunotherapy can be improved, offering a broader clinical benefit
10.1172/JCI57813 107
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The sustained elevation pattern favors different outcomes: a 2008 study in elderly hip fracture patients showed MK-677 25 mg daily improved gait speed and reduced falls by 30% over 12 months
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