Herbette S, Roeckel-Drevet P, Drevet JR
Risks and Side Effects While many users report no immediate side effects, risks exist: Unknown long-term safety (no large-scale human trials)
Given the continued growth of the obesity epidemic, primary care providers should prescribing GLPs for patients with nondiabetic obesity
Retatrutide, a triple GLP-1/GIP/glucagon receptor agonist, is studied in metabolic research
Clinical studies provide direct evidence: GLP-1 analogue therapy significantly reduced sCD163 (a marker of inflammatory macrophage activation), independent of changes in body weight, fructosamine, and HbA1c
Due to distinct tissue expression of receptors, MT-2 is incorporated alongside selective antagonists, genetic models, or specific interventions to attribute observed effects to receptor subtypes