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Description

Herbette S, Roeckel-Drevet P, Drevet JR

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Risks and Side Effects While many users report no immediate side effects, risks exist: Unknown long-term safety (no large-scale human trials)

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Given the continued growth of the obesity epidemic, primary care providers should prescribing GLPs for patients with nondiabetic obesity

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Retatrutide, a triple GLP-1/GIP/glucagon receptor agonist, is studied in metabolic research

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Clinical studies provide direct evidence: GLP-1 analogue therapy significantly reduced sCD163 (a marker of inflammatory macrophage activation), independent of changes in body weight, fructosamine, and HbA1c

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Due to distinct tissue expression of receptors, MT-2 is incorporated alongside selective antagonists, genetic models, or specific interventions to attribute observed effects to receptor subtypes

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