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Cross-class GIP functional potency retatrutide GIPR EC50 0.0643 nM (Coskun 2022) vs tirzepatide GIPR EC50 1.01 nM (Willard FS, et al

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That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it