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Patients with pre-existing gastrointestinal conditions, those who have undergone bariatric surgery (who typically require specific bariatric-formulation supplements), or individuals following restrictive diets (vegetarian, vegan) may enter GLP-1 treatment with suboptimal nutrient status
For now, experts agree that any direct effect on blood pressure is likely secondary to and smaller than the impact of weight loss itself
To overcome these limitations, a number of pharmacological approaches have been developed over the past decades, but these drugs are generally of fairly limited efficacy, expensive and can in some cases cause significant side effects
Reconstitution with bacteriostatic water (BAC water) is the standard preparation step used in published research protocols