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Semaglutide is typically administered through a titration process, starting with a low dose that gradually increases to maximize efficacy and minimize side effects
This triple mechanism distinguishes it from existing approved agents semaglutide, for example, acts on the GLP-1 receptor only, whilst tirzepatide is a dual GIP/GLP-1 receptor agonist and is being investigated to determine whether broader receptor engagement offers additional metabolic benefit
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Conditioned taste aversion study Lean mice were trained to consume their daily water requirements over 1 h, then given access to saccharin-sweetened Kool-Aid, followed immediately by IP injection of a potentially aversive stimulus (vehicle, agonist, or LiCl 0.15 M in a volume equivalent to 2% body weight as positive control)
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