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Key points The results of the EMPA-REG OUTCOME trial fundamentally transformed cardiovascularkidneymetabolic medicine by demonstrating that a glucose-lowering drug (a sodiumglucose cotransporter 2 (SGLT2) inhibitor) could reduce cardiovascular death, hospitalization for heart failure and the progression of chronic kidney disease in patients with type 2 diabetes mellitus

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If irritation continues, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use and contact your provider