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Doses above 1.5mg produce nausea in 5070% of subjects regardless of receptor sensitivity
Is there more to GABA than synaptic inhibition
doi: 10.1016/j.cmet.2022.07.013 80 le RouxCWSteenOLucasKJStartsevaEUnseldAHennigeAM
In summary, GLP-1 and GLP-1R show expression in a variety of tissues and the best-studied and most currently clinically relevant effects of GLP-1 is its ability to act as an incretin hormone and reduce appetite, given the global prevalence of T2D and obesity
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