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Metformin and Ozempic both commonly have digestive side effects, including abdominal pain, heartburn, nausea, vomiting, diarrhea, and constipation
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In fact, during recent years, Calr has been implicated to play a pivotal role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule [73-75] that might be involved as an ER-resident chaperone in AD and PD [76-78]
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