semaglutide and cardiovascular outcomes in obesity without diabetes journal club patients with and prevalent heart failure: a prespecified analysis of the SELECT trial Semaglutide, inflammatory markers and cardiovascular

Frank Lee, answers your questions about semaglutide and tirzepatide

While some people notice some of the effects of the medication, such as fewer cravings between meals, within a few weeks, the weight loss results of the treatment often take a few months to become apparent

"Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line"

In patients with type 2 diabetes mellitus, treatment with semaglutide injection 1 mg resulted in reductions in glucose in terms of absolute change from baseline and relative reduction compared to placebo of 29 mg/dL (22%) for fasting glucose, 74 mg/dL (36%) for 2-hour postprandial glucose and 30 mg/dL (22%) for mean 24-hour glucose concentration

The goal of managing diabetes through healthy behaviour interventions is meant to keep glucose levels within a target range to minimize side effects of the disease and prevent or delay potentially irreversible complications (i.e., blindness, heart disease, kidney problems and lower limb amputations)

J Clin Invest 55(6):12029 Modi A, Agrawal A, Morgan F (2017) Euglycemic diabetic ketoacidosis: a review