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Semaglutide, also known by the brand names Ozempic, Rybelsus and Wegovy, is an FDA-approved once-weekly GLP-1 receptor agonist manufactured by Novo Nordisk

These systems typically employ temperature- or pH-sensitive biodegradable polymers that form viscoelastic depots in situ, facilitating controlled release of therapeutic agents such as GLP-1 receptor agonists while circumventing systemic toxicity [45]

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However, throughput is low and it uses high levels of solvent typically acetonitrile (ACN)/water with trifluoroacetic acid which creates an environmental burden