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Melanotan 2 is a non-selective agonist of the melanocortin receptors which was originally developed as a tanning peptide

In the stomach, hydrochloric acid releases B12 from food proteins, after which it binds to intrinsic factor and travels to the terminal ileum for absorption

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These side effects occur because tirzepatide binds to receptors in brain regions that regulate appetite and stomach emptying, triggering temporary digestive discomfort

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DSIP does not solve this alone