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Semaglutide has been structurally modified to resist DPP-4 degradation and to bind to albumin, resulting in a significantly extended half-life of approximately one week

Proc Natl Acad Sci USA 92 : 10281032 Girnita A, Girnita L, Prete Fd F, Bartolazzi A, Larsson O, Axelson M (2004) Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth

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