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As treatment continues, temporary periods of stability can appear even when the medication is working as intended

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Maintaining this mucosal layer requires a constant supply of specific amino sugars and nutrients

2010 ASCO Annual Meeting, 2010

The impact we are seeing in OA might be real, but we have to define it more clearly. Although no data are conclusive yet, preclinical studies have shown that GLP-1 receptor agonists can inhibit the NF-kB pathway, a key pathway involved in inflammation and cartilage destruction, according to Lane

doi:10.1096/fj.09-142307 Malinda KM, Goldstein AL, Kleinman HK