While there are big reasons for this, like well-publicized research about the impact alcohol has on health and a general decline in social activities among Gen Z, one connection thats only just getting some attention is that between GLP-1 medications, like semaglutide and tirzepatide, and alcohol use
Hernndez et al
Patients taking medication for lifestyle-related comorbid diseases, such as hypertension, dyslipidemia, and diabetes, were included
Manage Stress Persistent stress results in higher cortisol levels which negatively affect testosterone production
However, due to limitations in methodology and potential bias, the certainty of the evidence is low
Retatrutide is a novel once-weekly triple agonist for the GLP-1R, GIPR, and GCGR receptors, showing a stronger action on the human GIP receptor, and exerting weaker effects on the GLP-1 and glucagon receptors