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Nasal delivery is the least-established route , with emerging interest for neurological and brain-adjacent applications, but limited human data to date

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The figure shows the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by a riboflavin (FAD)-dependent enzyme (methylenetetrahydrofolate reductase

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10.1021/acs.molpharmaceut.7b00025 24 DengC.XuX.TashiD.WuY.SuB.ZhangQ

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However, some people have complained of diarrhoea, nausea, gastrointestinal pain, vomiting, headaches, and trouble sleeping

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Butler PD, Javitt DC (2005)

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