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History Scientific interest in NNMT increased substantially during the early 2000s as researchers discovered its involvement in metabolic regulation, cellular methylation processes, and adipose tissue function

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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

PMID 21436999

It is primarily studied for its ability to reduce fat cell size, increase cellular energy Mechanism of Action: 5-Amino-1MQ blocks the enzyme NNMT, which is frequently overexpressed in fat tissue, thereby reducing fat accumulation and stimulating metabolism