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Provider-Guided Assessment: Who Should Consider Semaglutide and Why Semaglutide is most appropriate for adults with BMI 30 kg/m (or 27 with weight-related comorbidities like hypertension or type 2 diabetes) who have failed lifestyle modification alone

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This systematic review aims to critically assess the mechanisms of action, usage trends, efficacy, and safety profiles of DHA-based products, synthetic melanocortin analogs, and less conventional agents such as forskolin and carotenoids

NICE guidance prioritises SGLT2 inhibitors for those with established or high risk of cardiovascular or kidney disease, with GLP-1 receptor agonists as add-on or alternative therapy where appropriate