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Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion During Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers

These typically last one to two weeks

Of note it is also FDA approved for treatment of obstructive sleep apnea

Forgoing fasting in this option improves dietary tolerance, reducing the acute side effects of rapid ketosis (61, 65)

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Tirzepatide is still within its original exclusivity period, while the original exclusivity period for semaglutide should have expired this year (2026)