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PSGAG inhibits some catabolic enzymes such as elastase, stromelysin, metalloproteases, cathepsin B1, and hyaluronidases, which degrade collagen, proteoglycans, and hyaluronic acid in degenerative joint disease

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doi: 10.1111/dom.14280, 43 FurmanB

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Anabolic steroid users have supraphysiologic androgen loads driving high substrate availability for aromatase

These mechanisms directly contribute to the development of reproductive disorders such as polycystic ovary syndrome (PCOS) [353] and asthenozoospermia [354]