gip vs glp 1 receptors Frontiers The mechanism of GLP-1 and

et al., Bioorg Med Chem Lett, 2015

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Interspecies scaling (for example, body-surface-area conversion) typically reduces a rodent mg/kg figure severalfold, and even a properly scaled number would still be a hypothetical exposure , not a validated dose

Also at higher doses, it acts on centers in the brain and suppresses appetite