Liang J, Huang F, Hao X, et al
| Insulin resistance markers | As much as 50% less | 24 to 48 weeks | No major cardiac events | Triglyceride reduction | Large, correlated with liver fat | 24 to 48 weeks | Weight Loss Retatrutide resulted in significant weight loss in multiple clinical trials
It is unexpected that retatrutide failed to increase FOC in LA
For approved compounds (semaglutide and tirzepatide) with insurance coverage, pharmacy access is the dominant strategy you get regulated supply, clinical oversight, and lower cost after insurance
On low-energy days, do fewer sets but maintain the weight on the bar
Semaglutide works best at consistent, steady levels