A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study was done to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of orforglipron
doi:10.1038/nrgastro.2015.150
10.3390/nu11092092 69 DyskenM
doi: 10.1007/s10620-025-08964-6 104 AndersonSRAyoubMCoatsSMcHenrySTanTDeepakP
Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4
Methods Study design Representatives of the companies Bristol-Myers Squibb, Novo Nordisk, Sanofi, Merck, Novartis, Boehringer Ingelheim and Takeda were contacted with the request to provide the event numbers of acute pancreatitis with the respective drug and non-incretin comparators as well as the corresponding number of patient-years of exposure (PYOs) for the approved GLP-1 receptor agonists exenatide twice daily, exenatide weekly, liraglutide and lixisenatide, as well as the DPP-4 inhibitors sitagliptin, saxagliptin, vildagliptin, alogliptin and linagliptin