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Sakurabayashi T, Miyazaki S, Yuasa Y, Sakai S, Suzuki M, Takahashi S
Elias-Oliveira J, Leite JA, Pereira IS, Guimaraes JB, Manso G, Silva JS, Tostes RC, Carlos D
Liability 2: Strong CYP3A4 inhibition leads to dangerous drug interactions
Primary applications: wound healing (closure kinetics, collagen organization, tensile strength), tendon and ligament regeneration (Achilles transection, biomechanical testing), gastroprotection (NSAID protection, mucosal barrier, fistula healing), angiogenesis (HUVEC tube formation, VEGF expression, CAM assays), neuroprotection (gut-brain axis, neuroinflammatory reduction), and inflammation studies (cytokine modulation, ERK1/2 pathway)
(Mosk) 42 (4), 701706 (2008)
This combination works through complementary pathways that enhance nitric oxide (NO) production, bioavailability, and stability -- delivering benefits that exceed simple addition of their individual effects
