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Feeling winded after light activity can be related to the anemia a B12 deficiency can cause

Superposition of PF-06372222-bound crystal structure (containing the C347 6.36b F mutation), with crystal structure based molecular dynamic simulations of F347 shown in blue (500 ns) and of simulations C347 (6.36b mutated back to cysteine) shown in pink (500 ns)

This was confirmed in another study by Yamabe et al

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They need to gradually get used to higher and higher doses

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