Specifically, this meta-analysis combined the results of 19 clinical trials of vitamin E supplementation that mostly focused on secondary prevention and, as such, included subjects with pre-existing conditions, including heart disease, end-stage renal failure, and Alzheimer's disease
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Tsoyi K, Park HB, Kim YM, et al
Separate mechanism from outcome
1 This translates into a lower risk of hypoglycemia compared to other diabetes treatment options like sulfonylureas and insulin
Skin sensitivity has not been identified as a primary safety signal in published Phase 2 trial data, though injection site reactions are expected with subcutaneous administration