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2012;67:19 e119

PMID: 36631836

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The investigators reported that LR3-IGF-1 produced enhanced potency in the presence of cell-secreted IGFBPs, with the magnitude of enhancement attributable to the reduced-IGFBP-binding property of the analog rather than to increased intrinsic receptor potency

The newly formed citrulline is rapidly recycled to arginine by arginosuccinate synthase and arginosuccinate lyase, making the arginine-citrulline-NO cycle a self-sustaining engine for endothelial homeostasis

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