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Published Phase 2 data shows: Dose Group Discontinuation Due to AE Placebo 0% 1 mg 2.9% 4 mg (escalated) 5.7% 8 mg (escalated) 5.0% 12 mg (escalated) 8.3% For context, discontinuation rates in semaglutide 2.4 mg trials (STEP program) were approximately 7%, and tirzepatide 15 mg trials (SURMOUNT) reported approximately 6-7%
Fibromyalgia affects up to 3% of the general population and is a syndrome characterised by widespread pain, fatigue, sleep disturbances, and cognitive dysfunction, somatic symptoms, and psychiatric disorders [90]
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As with any medication regimen changes or initiation should be done under medical supervision due to potential side effects and interactions with other medications.
"[Losing] five percent of your body weight every three months is considered clinically meaningful that's roughly a pound a week or less." Losing weight too quickly can worsen fatigue and accelerate muscle loss
Many patients notice the slowdown in the first 24 weeks
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