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Kinetic modelling Kinetic modelling is a mathematical description that described a dynamic parameter as it changes over time, typically by combining the input function of contrast agent/tracer in arterial blood and the transfer of the tracer in tissue (tissue uptake curve)

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The commentary accompanying the original paper highlighted these results as evidence that senescent cell elimination could produce systemic rejuvenation rather than isolated organ-specific improvements (Krimpenfort & Berns, 2017)