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Furthermore, we applied rigorous methods, including the use of an active comparator and new user cohort design, which reduces confounding and mitigates time related and selection bias caused by prevalent users.5253 Our study has several limitations

Retatrutide (also known as LY3437943) is a synthetic peptide designed to simultaneously agonize three metabolic hormone receptors GLP-1R, GIPR, and GcgR representing a pharmacological approach that goes substantially further than first-generation GLP-1 receptor agonists

Third, we may not be controlling the TLR4 ligands, since there are many TLR4 ligands other than LPS

Proper injection technique is essential for ensuring optimal drug delivery, minimizing discomfort, and reducing the risk of injection site complications