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Whereas creatinine-based estimates of GFR are able to predict risks associated with declining kidney function when eGFR levels fall to 60 mL/min/1.73m2 or less, GFR estimates based on cystatin C level are predictive at approximately 85 mL/min/1.73m2

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20,21 In this approach, androgenetic haploid embryonic stem cells (AG-haESCs) with deletions in the differentially methylated regions of the imprinted loci H19 -DMR and IG -DMR (termed DKO-AG-haESCs) are injected into the oocyte cytoplasm to efficiently produce gene-modified animals, referred to as semi-cloned mice

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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached

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