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Fat-selective weight loss would be an additional advantage, as the STEP-1 (NCT03548935) trial demonstrated that once-weekly semaglutide 2.4 mg resulted in 3.4 kg (7.5 lb) more loss in lean body mass compared to placebo

However, these appear to be best for helping patients maintain their goal weight after weight loss rather than getting them to their goal weight

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Prescription of guideline-directed medical therapies in patients with diabetes and chronic kidney disease from the CURE-CKD Registry, 2019-2020