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EVIDENCE GRADES Lau 2021 Lancet dose-dependent placebo-subtracted weight loss to ~10.8% at 26 weeks
Each case is very different
Who Should Consider Each Option Neither Retatrutide nor Wegovy is the right choice for everyone in every situation
A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]
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The Phase 2b protocol used one dose per day for 12 weeks
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