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This suggests an increased vulnerability to oxidative damage
565 combination therapy, where if monotherapy is ineffective, medications with different mechanisms of action may be combined
Sci Rep 7(1):1274
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After that, the unneutralized NAPQI attaches itself to proteins in the mitochondria, causing oxidative stress and ATP depletion, altering mitochondrial function, and raising the generation of oxygen species that are reactive (ROS)
PMID 25674096
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