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Spontaneous post-marketing reports occasionally mention sleep difficulties in people taking semaglutide or other GLP-1 receptor agonists, though these reports remain anecdotal rather than systematically documented

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In Phase 2 trials, participants lost an average of 24.2% of their body weight at 48 weeks on the 12mg dose, the highest weight loss ever recorded for any GLP-1 class medication

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His level of autistic symptoms as assessed across lifespan were significantly elevated (Social Communication Questionnaire life-time version score 24)

Glutathione S-sulfonate, a sulfur dioxide metabolite, as a competitive inhibitor of glutathione S-transferase, and its reduction by glutathione reductase