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In controlled trials they have not reliably increased strength or athletic performance

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2024 Feb 21;22(1):192

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist, may induce a specific microbial footprint that differs from pure GLP-1 agonism, as GIP signaling independently participates in lipid handling and mucosal immune regulation, potentially modifying the nutrient-delivery profile to the gut ( Overall, differences between studies likely reflect heterogeneity in patient populations, diet, baseline microbiota, and treatment duration

Critics warn its a nutritional minefield

Some vendors proactively submit samples for third-party testing