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The absence of nutrient diversity, imbalanced macronutrient intake and decreased phytochemical intake can lead to a loss of gut microbial diversity, including keystone bacteria, and simultaneously increased growth of opportunistic species, contributing to subsequent dysbiosis, reduced short-chain fatty acid (SCFAs) production, and inflammation

5.12 Acute Gallbladder Disease Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing

For example, in clinical trials of Wegovy (semaglutide), eructation was reported in 5.8% of patients versus 0% in the placebo group