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What they probably didnt mention is that functional B12 deficiency can begin at levels well above the standard cutoff and that by the time serum B12 drops below the labs flagged range, neurological damage may already be underway
A patient with an unfavorable GLP1R variant may require higher semaglutide exposure to achieve the same appetite-suppressing effect as someone with an optimized variant
doi: 10.3389/fnut.2022.950062 129 ZouCChenYLiHLiWWeiJLiZet al
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