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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels

It should be GHK or tri-peptide-1, not GHK-Cu or copper peptide

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Glutathione biosynthesis As glutamate is one of the three amino acid constituents of glutathione and can also supply the TCA cycle through the production of -KG, NRF2 may support both the antioxidant response and NADPH production through the control of glutamine metabolism

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Walsh, J