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Studies such as STEP 1, STEP 4, and STEP 5 published in the New England Journal of Medicine and JAMA did not identify shingles as a treatment-emergent adverse event occurring at higher rates in the semaglutide group compared to placebo

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In myocytes isolated from myopathy patients with an iron-sulfur cluster deficiency, elevated FGF21 expression and secretion correlate with increased expression of ketogenic enzymes ( Thirdly, protein restriction in humans (283) and rodents (284), increases circulating FGF21

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