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At the cellular level, insulin resistance can be defined as reduced signal transduction along the PI3KAKTmTOR pathway per unit of insulin, resulting in decreased glucose uptake per unit of insulin in adipocytes and skeletal muscle or decreased suppression of hepatic gluconeogenesis

2 Genital melanotic macules present clinically with multifocal irregular brown pigmentation and irregular margins and are up to 2 cm in diameter

These mechanisms are related, but they are not interchangeable

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GHK-Cu stimulates synthesis of collagen (types I and III), dermatan sulfate, chondroitin sulfate, and the small proteoglycan decorin

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