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The HPA axis initiates a response in times of stress, stopping the activity through negative feedback, engaging the hippocampus and the paraventricular nucleus of the hypothalamus

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Several mechanisms may contribute to the positive effects of GLP1RAs in preventing HF and influencing the outcomes for patients with either HFpEF or HFrEF

doi: 10.1007/s11306-019-1550-1 68 HornungSDuttaSBitanG