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The mechanism involves glucose-dependent insulin secretion, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia when used as monotherapy

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This reality makes cost sustainability and tolerance at maintenance doses crucial considerations when planning treatment

doi:10.1016/S0301-4622(02)00023-6

Additionally, patients using both treatments may attribute weight loss or adverse effects to the wrong agent, complicating clinical assessment

Clinical trials as mentioned by the research studies have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial)