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In populations with added comorbidities, results are lower: TRIUMPH-2 (obesity + diabetes) showed 20.8%, TRIUMPH-3 (obesity + cardiovascular disease) showed 22.6%, and TRANSCEND-T2D-1 (diabetes-specific, 40 weeks) showed 16.8% all consistent with patterns seen across the GLP-1 drug class, where comorbidities reduce achievable weight loss

Crepey-looking texture: helps skin look smoother, softer and more moisturised with consistent use

Dullemeijer C, Verhoef P, et al

No signs of AI generation or manipulation

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Antidepressants or SSRIs: There are no direct contraindications, but you should still monitor changes in appetite, mood, and energy