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It should be noted that these studies measured total Cbl levels, but as previously mentioned, the biologically available form of Cbl, TCN2-Cbl, comprises only approximately 2030% of the total Cbl level, which may lead to a significant number of false negatives for clb deficiency
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It is recommended to start with a low dose of the peptide combination and gradually increase it over time in order to minimize the risk of side effects
Actin is the cellular protein that forms the cytoskeletal rails along which repair cells migrate
Nat Rev Neurol 19:715736
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