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While GLP-1RA monotherapy may be sufficient for many patients, particularly those without renal risk, combination therapy may be particularly beneficial for high-risk subgroups, such as those with CKD

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Presented at the American Heart Associations 2023 Scientific Sessions (1113 November, Philadelphia, USA), the results of the SELECT trial showed that overweight or obese people without diabetes taking semaglutide for more than three years had a 20% lower risk of heart attack, stroke or death due to cardiovascular disease and lost an average of 9.4% of their body weight

The peptide backbone is derived from GIP and modified to introduce glucagon receptor activity

Clinical studies have demonstrated that semaglutide can help individuals lose a significant amount of weight

According to the brand's weight-loss page, semaglutide is available as a once-weekly injection