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On its face, it was a simple case of miscommunication
Proc Nat Acad Sci USA 1989
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Wang WQ, Liu L, Xu HX, et al
The treatment-policy estimand is closer to intention-to-treat: it estimates the effect regardless of whether participants stayed on treatment or used rescue therapies
Homocysteine, as a component of the one-carbon cycle, can be converted to methionine via the trans-methylation pathway or cysteine via the trans-sulfuration pathway 15,35
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