They need to be confirmed in larger trials
Key takeaways: GLP-1 receptor agonists (e.g., semaglutide, liraglutide, tirzapeptide) are now approved for weight loss for overweight teens and adults
it enables cells to cope with various forms of stress (e.g., nutrient deprivation, endoplasmic reticulum (ER) stress, pathogen infection, and hypoxia) and is considered a survival mechanism 5
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doi:10.4238/2013.May.14.2 Lampe JW (2007) Diet, genetic polymorphisms, detoxification, and health risks
It also slowed gastric emptying and reduced appetite, which immediately made it different from other diabetes hormones. The problem was timing: natural GLP-1 is broken down within minutes, making it impractical as a medication